Man Booker Prize for Fiction, 2011, Short-listed, The Sisters Brothers.
Scotiabank Giller Prize, 2011, Short-listed, The Sisters Brothers.
Rogers Writers' Trust Fiction Prize, 2011, Winner, The Sisters Brothers.
Governor General's Literary Award: Fiction, 2011, Winner, The Sisters Brothers.
Publishers Weekly Best Book, 2011, Commended, The Sisters Brothers.
Amazon.ca Best Books: Editors' Pick, 2011, Commended, The Sisters Brothers.
Amazon.ca Best Books: Canadian Fiction, 2011, Commended, The Sisters Brothers.
Globe and Mail Top 100 Book, 2011, Commended, The Sisters Brothers.
Quill and Quire Book of the Year, 2011, Commended, The Sisters Brothers.
Toronto Star Reviewers' Top 100 Books, 2011, Commended, The Sisters Brothers.
Maclean's Magazine Best Books, 2011, Commended, The Sisters Brothers.
Pacific Northwest Booksellers Association Book Award, 2012, Winner, The Sisters Brothers.
CBC Bookie Awards: Literary Fiction, 2012, Short-listed, The Sisters Brothers.
Stephen Leacock Memorial Medal, 2012, Winner, The Sisters Brothers.
Walter Scott Prize, 2012, Short-listed, The Sisters Brothers.
Oregon Book Awards: Ken Kesey Award for Fiction, 2012, Winner, The Sisters Brothers.
CBA Libris Award: Fiction Book of the Year, 2012, Winner, The Sisters Brothers.
CBA Libris Award: Author of the Year, 2012, Short-listed, The Sisters Brothers.
IMPAC Dublin Literary Award, 2013, Long-listed, The Sisters Brothers.
Google Play International Author of the Year, 2012, Short-listed, The Sisters Brothers.
Prix des libraires du Quebec, 2013, Winner, The Sisters Brothers.

[Patrick] DeWitt has produced a genre-bending frontier saga that is exciting, funny, and perhaps unexpectedly, moving.
- Publishers Weekly, starred review
... sheer brilliance ...
- Chatelaine
DeWitt’s inspired, many-layered yarn is as entertaining and as stylistically accomplished as it is unsettling and most original in its revisiting of what remains a glorious genre.
- Irish Times
. . . a darkly comic, compelling and surprising story . . . I doubt I'll find a more entertaining and thoughtful novel this year.
- Uptown Winnipeg
Fully invested, DeWitt is a hilarious, wry wordsmith and a masterful storyteller. The Sisters Brothers, with its sharp edges and instinctive compassion, is far from historical displacement or genre escapism. It is art worthy of the status, regardless of context or -ism.
- Rover Arts
. . . gritty . . . deadpan . . . very comedic . . . opens new doors in the imagination.
- New York Times Book Review
[Patrick deWitt] has taken the typical saga and, with laser-sharp prose, masterful storytelling, and an eccentrically perfect combination of humor, violence, lust, and pathos, has turned it completely upside-down. Never has the Old West seemed so simultaneously and page-turningly beautiful, tragic, and comedic, or a cowboy so delightfully neurotic.
- Charlotte Viewpoint
America seems anything but beautiful in Patrick DeWitt’s quirky and ultimately touching new novel The Sisters Brothers.
- Anniston Star
Patrick deWitt has written an Old West tale that conjures up the colourful images of a spaghetti western filled with stark realism, eccentric characters and black humour . . . If you’re looking for an unforgettable western, grab this one.
- Monday Magazine
. . . a book that’s both a heck of a lot of fun to read and surprisingly compelling when it ends -- one that both your hipster brother and your straight-arrow dad will get a kick out of.
- Wisconsin Capital-Times
. . . comic . . . engaging . . . the brothers' poetic banter and the book’s bracing bursts of violence keep this campfire yarn pulled taut.
- Onion AV Club
The Sisters Brothers is a bold, original and powerfully compelling work, grounded in well-drawn characters and a firm hold on narrative. When they say “They don’t write em like that anymore,” they’re wrong.
- Globe and Mail
Bursting with vitality and driven along by a terrific pulpy energy, The Sisters Brothers is the kind of book you may well end up wholeheartedly recommending to friends.
- Herald Scotland
. . . hilarious, dark, twisted and compelling.
- Canada Arts Connect Magazine
. . . fresh, hilariously anti-heroic, often genuinely chilling, and relentlessly compelling. Yes, this is a mighty fine read, and deWitt a mighty fine writer.
- National Post
Wandering his Western landscape with the cool confidence of a practiced pistoleer, deWitt's steady hand belies a hair trigger, a poet's heart and an acute sense of gallows humor . . . It's easy to imagine John C. Reilly - who is set to star in the film version of the book - lumbering through this breezy, pitch-black comedy's cinematic scenes.
- Time Out New York
. . . darkly hilarious . . . riveting . . . deWitt welcomingly reimagines the [Western] genre.
- ZYZZYVA
[Patrick deWitt] frequently crosses into comic territory to produce a story that's weirdly funny, startlingly violent and steeped in sadness.
- Washington Post
In The Sisters Brothers, a diabolical combination of Laurel and Hardy and Butch Cassidy and the Sundance Kid (with a touch of Don Quixote and Sancho Panza, just to emphasise the high literary stakes) deWitt has ensured another unforgettable pair their place in fictive lore.
- Telegraph
. . . original, entrancing and entertaining . . .
- Denver Post
So subtle is deWitt's prose, so slyly note-perfect his rendition of Eli's voice in all its earnestly charming 19th-century syntax, and so compulsively readable his bleakly funny western noir story, that readers will stick by Eli even as he grinds his heel into the shattered skull of an already dead prospector.
- Maclean's
. . . edgy and unyielding . . . The Sisters Brothers gives readers a sense of adventure without ever having to stare down the barrel of a gun.
- Weekender
. . . wryly comic, heartbreakingly sentimental, and immensely likable . . .
- Georgia Straight
DeWitt has invigorated [the] well-worn path [of the classic Western] with wit, style, and imagination.
- New West
The Sisters Brothers is a bloody, nightmarish frontier road trip that seems at times like something out of Cormac McCarthy, yet somehow merges laughter and hope with suffering, death and betrayal. [...] Like an alchemist, deWitt has refined and purified the base metals of black comedy and the western to produce literary gold.
- Winnipeg Free Press
The Sisters Brothers has a cadence and flow to its prose and the reader can almost hear Eli's laconic narration as the pages turn . . . here is a hardcover that practically holds a Colt to your head and growls: read me.
- Winnipeg Review
. . . spirited and often humorous . . . Patrick deWitt's picaresque narrative works with a wink and a nod of reverence, squaring with recent revivals of the Western in popular culture, namely HBO's Deadwood.
- Oregonian
. . . [an] unsettling, compelling and deeply strange picaresque novel.
- Independent
Violent, funny and strangely touching, [The Sisters Brothers is] destined for a spot on many best-of-2011 lists.
- Edmonton Journal
. . . a witty noir version of Don Quixote . . . hugely entertaining.
- Financial Times
. . . gory, mesmerizing . . . carries a strong echo of Pulp Fiction . . . seduces us to its characters, and draws us on the strength of deWitt's subtle, nothing-wasted prose.
- Cleveland Plain Dealer
. . . imaginative and ebullient . . . revels in the hilarious life and times of two gunslingers, Eli and Charlie Sisters.
- Boston Globe
. . . cinematic, wry and mannered . . . DeWitt['s] ability to distill an image with a couple of well-chosen words and the precision and intensity of his language gives [The] Sisters [Brothers] a dreamlike aura.
- Philadelphia City Paper
I doubt very much I'll read a funnier, more original book than this picaresque, Wild West tale . . . a terrifically spun yarn . . . masterfully strange and wonderful . . .
- Toronto Star
. . . smooth and seamless, shot through with dark humor . . . as easy to slip into as the old HBO series 'Deadwood.'
- LA Times
. . . a lushly voiced picaresque story . . . It's a kind of True Grit told by Tom Waits.
- Esquire
There is something irresistibly cinematic about this quirky tale, a Coen brothers-style strangeness that paradoxically celebrates an unlikely humanity.
- Edmonton Journal